Epcoritamab in Previously Treated WM
NCT06510491 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2026-03-13
Summary
This study is being done to determine if epcoritamab can be used to treat participants with previously treated Waldenstrom Macroglobulinemia (WM).
The names of the study drug involved in this study is:
-Epcoritamab (a type of antibody)
Conditions
- Waldenstrom Macroglobulinemia
- B-Cell Lymphoproliferative Disorder
Interventions
- DRUG
-
Epcoritamab
Bispecific antibody, via subcutaneous (under the skin) injection per protocol.
Sponsors & Collaborators
-
Genmab
collaborator INDUSTRY -
Gottfried von Keudell, MD PhD
lead OTHER
Principal Investigators
-
Gottfried von Keudell, MD · Beth Israel Deaconess Medical Center
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-12-06
- Primary Completion
- 2027-04-30
- Completion
- 2027-12-31
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
A Phase II Trial of Ofatumumab in Subjects With Waldenstrom's Macroglobulinemia
NCT00811733 ·Status: COMPLETED ·Phase: PHASE2
-
Carfilzomib With or Without Rituximab in the Treatment of Waldenstrom Macroglobulinemia or Marginal Zone Lymphoma
NCT03269552 ·Status: TERMINATED ·Phase: PHASE2
-
Investigating the Safety and Efficacy of Rituximab and Pembrolizumab in Relapsed/Refractory Waldenström's Macroglobulinaemia
NCT03630042 ·Status: COMPLETED ·Phase: PHASE2
-
Randomised Trial in Waldenstrom's Macroglobulinaemia
NCT01592981 ·Status: COMPLETED ·Phase: PHASE2
-
Rituximab and Ibrutinib (RI) Versus Dexamethasone, Rituximab and Cyclophosphamide (DRC) as Initial Therapy for Waldenström's Macroglobulinaemia
NCT04061512 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Alemtuzumab in Treating Patients With Waldenstrom's Macroglobulinemia
NCT00081068 ·Status: WITHDRAWN ·Phase: PHASE2
-
Epcoritamab Compared to Observation for Treating B-cell Lymphoma Patients Not in Complete Remission After CD19-directed CAR-T Therapy
NCT06238648 ·Status: RECRUITING ·Phase: PHASE2
-
Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)
NCT04663347 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome
NCT04623541 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Subcutaneous Epcoritamab With or Without Lenalidomide as First Line Therapy for Diffuse Large B-Cell Lymphoma
NCT05660967 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Phase 2 Trial of Epcoritamab in Combination With Rituximab-mini CVP for Older Unfit/Frail Patients or Anthracycline-Ineligible Adult Patients With Newly Diagnosed Diffuse Large B-cell Lymphoma
NCT06045247 ·Status: RECRUITING ·Phase: PHASE2
-
A Single-Arm, Expanded Access Study of Zanubrutinib in Participants With B-cell Malignancies
NCT04052854 ·Status: NO_LONGER_AVAILABLE
-
Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Waldenstrom's Macroglobulinemia
NCT00060294 ·Status: TERMINATED ·Phase: PHASE1
-
Epcoritamab-CAR T Cells for Large B-cell Lymphomas
NCT06458439 ·Status: RECRUITING ·Phase: PHASE2
-
Correlation of FC Gamma RIIIA Receptor Response in Patients With Waldenstrom's Macroglobulinemia
NCT00142155 ·Status: COMPLETED ·Phase: NA
-
Trial of Ixazomib, Dexamethasone and Rituximab in Patients With Untreated Waldenstrom's Macroglobulinemia
NCT02400437 ·Status: COMPLETED ·Phase: PHASE2
-
Outpatient Epcoritamab as 2L in NTE R/R DLBCL
NCT06811272 ·Status: RECRUITING ·Phase: PHASE2
-
Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Waldenstrom's Macroglobulinemia
NCT00060346 ·Status: TERMINATED ·Phase: PHASE2
-
Trial Comparing Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia
NCT00566332 ·Status: COMPLETED ·Phase: PHASE3
-
Everolimus, Bortezomib and/or Rituximab in Patients With Relapsed/Refractory Waldenstrom's Macroglobulinemia
NCT01125293 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Study of Epcoritamab in R/R Primary Diffuse Large B-cell Lymphoma of the CNS Treated With Lenalidomide and Rituximab
NCT06931652 ·Status: RECRUITING ·Phase: PHASE2
-
Epcoritamab and Rituximab for First-line Follicular Lymphoma
NCT05783609 ·Status: RECRUITING ·Phase: PHASE2
-
Expanded Access to Epcoritamab
NCT05692050 ·Status: NO_LONGER_AVAILABLE
-
Everolimus (RAD001) in Primary Therapy of Waldenstrom's Macroglobulinemia
NCT00976248 ·Status: COMPLETED ·Phase: PHASE2
-
Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma
NCT04840602 ·Status: RECRUITING ·Phase: PHASE2