MedTrace Logo

Vancomycin and Negative Pressure Therapy for Post-sternotomy Deep Sternal Wound Infection

NCT06506032 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2024-07-22

No results posted yet for this study

Summary

Only a limited number of studies have been published that monitored the penetration of antibiotics from blood into exudate in patients treated with negative pressure wound therapy (NPWT), and that evaluated the adequacy of current dosage regimens according to antibiotic tissue concentrations. A higher migration rate of several antibiotics (including vancomycin) to exudate has been reported in patients with skin ulcers, skin defects, burns, and traumatic wounds treated with NPWT compared to patients without NPWT.

In the present study, the investigators will evaluate the pharmacokinetic profile and wound penetration of vancomycin in open-heart surgery patients with post-sternotomy deep sternal wound infection receiving NPWT.

Conditions

  • Post-Sternotomy Deep Sternal Wound Infection

Interventions

DRUG

Intravenous Vancomycin administration

Vancomycin was administered to the patients at the discretion of the physician

OTHER

Standard postoperative therapy

The patients received standard postoperative therapy

Sponsors & Collaborators

  • University of Ostrava

    collaborator OTHER

  • Masaryk University

    collaborator OTHER

  • Masaryk Memorial Cancer Institute

    collaborator OTHER

  • Technical University of Ostrava

    collaborator UNKNOWN

  • University Hospital Ostrava

    lead OTHER

Principal Investigators

  • Martin Kolek, MD,PhD · University Hospital Ostrava

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-07-30
Primary Completion
2023-12-31
Completion
2023-12-31

Countries

  • Czechia

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06506032 on ClinicalTrials.gov