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Endometriosis and Complement System

NCT06495151 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 58

Last updated 2024-07-12

No results posted yet for this study

Summary

Endometriosis is a chronic gynecological condition affecting nearly 10% of women of reproductive age. A definitive diagnosis of endometriosis requires laparoscopy. Studies aim to identify novel biomarkers to aid in the development of effective noninvasive diagnostic methods. Despite several theories, the full understanding of the etiopathogenesis remains elusive. A distorted immune response is thought to play a crucial role in the pathophysiology of endometriosis. This study aimed to evaluate whether the levels of alternative complement molecules change in the blood serum and peritoneal fluid of endometriosis patients compared to healthy subjects.

Conditions

  • Endometriosis
  • Complement System
  • Alternative Complement Pathway

Interventions

DIAGNOSTIC_TEST

Mannose-binding lectin-associated serine protease-3 (MASP-3) Level

Measurement of venous blood serum and peritoneal fluid levels of MASP-3 level by ELISA method.

DIAGNOSTIC_TEST

Adipsin Level

Measurement of venous blood serum and peritoneal fluid levels of adipsin level by ELISA method.

DIAGNOSTIC_TEST

Properdin Level

Measurement of venous blood serum and peritoneal fluid levels of properdin level by ELISA method.

DIAGNOSTIC_TEST

Complement Factor H (CFH) Level

Measurement of venous blood serum and peritoneal fluid levels of CFH level by ELISA method.

DIAGNOSTIC_TEST

Cancer Antigen 125 (CA-125) Level

Measurement of venous blood serum level of CA-125 level by ELISA method.

Sponsors & Collaborators

  • Ankara City Hospital Bilkent

    lead OTHER

Principal Investigators

  • Merve Didem Eşkin Tanrıverdi, MD · Ankara City Hospital Bilkent

Eligibility

Min Age
18 Years
Max Age
44 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-06-10
Primary Completion
2022-09-12
Completion
2022-10-07

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06495151 on ClinicalTrials.gov