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Investigation of Corticospinal Excitability Aspects of Itch and Pain

NCT06470737 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2024-11-22

No results posted yet for this study

Summary

The experiment consists of three experimental sessions conducted over a period of two weeks. In the first experimental session, we apply in your hand: either an injection of salt water (7% NaCl) or we apply small needles from the plant mucuna pruriens or histamine (1%). For 10 minutes after this, you are to assess the itch and pain you perceive. We will also apply non-invasive magnetic stimulations to your brain. During the experiment, you should fill in questionnaires. The second and third experimental sessions are conducted in the same way as the first session.

The purpose of this experiment is to investigate the changes appearing in the brain during artificially applied itch and pain corticomotor adaptations.

Conditions

Interventions

OTHER

Hypertonic Saline

A bolus injection of hypertonic saline (7% NaCl) will be administered to the FDI muscle using a 1 mL syringe with a disposable needle (27G), and the volume of the bolus will be 0.2 mL

OTHER

Histamine

A small drop of histamine dihydrochloride will be applied to a previously determined area on the volar forearm, followed by a prick through the drop

OTHER

Cowhage

This insertion is conducted by forceps using a stereo-microscope, and 30-35 spicules are gently rubbed into a 1 cm diameter skin area.

DEVICE

Transcranial magnetic stimulation (TMS)

Transcranial magnetic stimulation (TMS) will be used to evoke motor-evoked potentials (MEPs) in the muscle of interest and cortical responses (TMS-evoked potentials - TEPs) in the motor cortex with a figure-eight-shaped cone coil.

Sponsors & Collaborators

  • Aalborg University

    lead OTHER

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-07-01
Primary Completion
2024-09-30
Completion
2024-10-31

Countries

  • Denmark

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06470737 on ClinicalTrials.gov