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Effect of Ketamine, Amitriptyline and Their Combination on Itch

NCT06245564 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-01-30

No results posted yet for this study

Summary

Chronic itch affects approximately a fifth of the global population and is associated with substantial negative consequences for the affected individuals. Furthermore, there is a lack of efficient treat-ment options for chronic itch. Topical ketamine cream has been used successfully to relieve various forms of pain, and we hypothesize that topical ketamine relieves itch through a mechanism of action comparable to that in pain relief.

The aim of this project is to evaluate the effects of ketamine both alone and in combination with amitriptyline on histaminergic and non-histaminergic itch induced by histamine and cowhage, respectively.

Conditions

  • Itch

Interventions

DRUG

Ketamine 0.5%

Ketamine cream 0.5% will be applied in a 4x4 area in the forearm of each participant.

DRUG

Amitriptyline

Amitriptyline cream 1% will be applied in a 4x4 area in the forearm of each participant.

DRUG

ketamine + amitriptyline

A cream containing ketamine 0.5%, amitriptyline 1%, will be applied in a 4x4 area in the forearm of each participant.

OTHER

Vehicle

A vehicle cream will be applied in a 4x4 area in the forearm of each participant.

OTHER

Histamine

After the cream removal, itch will be induced using histamine in the first session

OTHER

Cowhage

After the cream removal, itch will be induced using cowhage in the second session

Sponsors & Collaborators

  • Aalborg University

    lead OTHER

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-08-20
Primary Completion
2024-12-31
Completion
2024-12-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06245564 on ClinicalTrials.gov