Promoting Neuroplastic Changes of Patients With TBI

Summary

This project will develop a wearable rehabilitation robot suitable for in-bed acute stage rehabilitation. It involves robot-guided motor relearning, passive and active motor-sensory rehabilitation early in the acute stage post-TBI including patients who are paralyzed with no motor output. The early acute TBI rehabilitation device will be evaluated in this clinical trial.

Conditions

• Traumatic Brain Injury

Interventions

DEVICE

Motor relearning training with wearable ankle robot

Ankle motor control relearning training under real-time feedback

DEVICE

Passive stretching with wearable ankle robot

Passive stretching under intelligent robotic control

DEVICE

Gamed-based active movement training with wearable ankle robot

Active movement training through movement games with robotic assistance

DEVICE

Passive movement with limited wearable ankle robot

Passive movement in the joint middle range of motion

DEVICE

Active movement training with limited wearable ankle robot

Active movement training without robotic assistance

DEVICE

Ankle/Wrist torque and motion measurement with limited wearable ankle/wrist robot

Ankle/Wrist torque and motion measurement with no real-time feedback

Sponsors & Collaborators

• The University of Texas Health Science Center, Houston

  collaborator OTHER

• University of Maryland, Baltimore

  lead OTHER

Principal Investigators

• Li-Qun Zhang · University of Maryland

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

30 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-05-01

Primary Completion

2029-08-31

Completion

2030-08-31