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Medication Related Osteonecrosis of the Jaws (MRONJ) in a Cohort of Patients Treated by Antiresorptive Drugs

NCT06457776 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 126

Last updated 2024-06-20

No results posted yet for this study

Summary

The objective of this prospective observational study is to investigate the incidence of Medication Related Osteonecrosis of the Jaws (MRONJ) in patients receiving antiresorptive drugs for oncohematologic reasons during a 5-year follow-up. Secondary objectives are to compare the different antiresorptive drugs in relation to the incidence of MRONJ and to identify any systemic as well as local risk factors.

Conditions

  • Osteonecrosis of the Jaw
  • Osteonecrosis Due to Drugs, Jaw
  • Osteonecrosis Due to Drug
  • Bisphosphonate-Associated Osteonecrosis
  • Bisphosphonate-Associated Osteonecrosis of the Jaw

Interventions

PROCEDURE

Dental management

The oral conditions of the included patients will be evaluated at baseline. When indicated, dental extractions will be performed before the beginning of Antiresorptive Therapy. Patients will then receive a six-months intervals follow-up, during which primary and secondary prevention of dental diseases will be performed.

Sponsors & Collaborators

  • Catholic University of the Sacred Heart

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-01
Primary Completion
2026-01-01
Completion
2028-01-01

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06457776 on ClinicalTrials.gov