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Medication-related Osteonecrosis of the Jaw (MRONJ) Registry

NCT02932501 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 518

Last updated 2024-03-20

No results posted yet for this study

Summary

Approximately 500 patients will be included in this patient registry. Data collection includes demographics, clinical data of underlying disease and use of bisphosphonates, denosumab and antiangiogenic drugs , degree and extension of osteonecrosis, osteonecrosis-specific treatment, outcomes and complications within 1 year after treatment.

Conditions

  • Medication-related Osteonecrosis of the Jaw
  • Bisphosphonate-Associated Osteonecrosis of the Jaw

Interventions

PROCEDURE

Conservative treatment

Disinfectant mouth rinses, Antibiotic therapy, Antifungal therapy

PROCEDURE

Surgical treatment

Superficial debridement, Complete removal of necrotic bone, Complete bone resection, When applicable revision and soft tissue coverage

PROCEDURE

Adjuvant non-surgical treatment

Hyperbaric oxygen therapy Pentoxifylline and tocopherol Ozone therapy Low level laser therapy Pain relief Anti-inflammatory treatment Platelet rich plasma Parathyroid hormone and teriparatide Bone morphogenetic protein

Sponsors & Collaborators

  • AOCMF

    collaborator OTHER

  • AO Clinical Investigation and Publishing Documentation

    lead OTHER

Principal Investigators

  • Risto Kontio, MD DDS PhD · Helsinki University Central Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-08-14
Primary Completion
2023-10-13
Completion
2024-04-30

Countries

  • United States
  • Finland
  • Germany
  • Netherlands
  • Qatar
  • Romania
  • Slovenia
  • South Korea
  • Spain
  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02932501 on ClinicalTrials.gov