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Prednisone for CRPS in Distal Radius Fracture

NCT06453447 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-05-01

No results posted yet for this study

Summary

Wrist fractures are the most prevalent adult fracture. Complex regional pain syndrome (CRPS) is a common complication that can occur, leading to permanent disability and is costly to the patient and healthcare system. In addition, amidst the opioid epidemic, the risk of increased opioid use in patients with CRPS prompts the need to find viable treatment strategies. This study aims to evaluate an anti-inflammatory medication, prednisone, in the early treatment of CRPS. Patients with wrist fractures who undergo surgical treatment will be randomized to receiving placebo vs prednisone for 2 weeks. Clinical assessments in the follow up period will be compared.

Conditions

  • Complex Regional Pain Syndromes
  • Distal Radius Fractures

Interventions

DRUG

Prednisone

40 mg PO once daily for 14 days starting day of surgery

DRUG

Placebo

Placebo tablet (cellulose) PO once daily for 14 days starting day of surgery

Sponsors & Collaborators

  • Canadian Orthopaedic Foundation

    collaborator OTHER

  • University of British Columbia

    lead OTHER

Principal Investigators

  • David Stockton, MD, MASc, FRCSC · University of British Columbia

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-10-10
Primary Completion
2027-05-31
Completion
2027-07-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06453447 on ClinicalTrials.gov