99mTc Labeled FAP Targeted Molecular Probe in Early Diagnosis of Tumors
NCT06438705 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 20
Last updated 2025-03-11
Summary
At present, radiopharmaceuticals targeting FAP have been developed for the diagnosis and treatment of various tumors. Considering the problems of fast tumor tissue clearance and short retention time in small molecule FAP inhibitors based on quinoline rings, this project optimized their ligands and developed a new FAP targeted technetium labeled molecular imaging probe for SPECT/CT imaging research to evaluate its safety in clinical application and its effectiveness in tumor diagnosis.
Conditions
- Head and Neck Tumor
- Lung Cancer
- Pancreatic Cancer
Interventions
- DIAGNOSTIC_TEST
-
SPECT-CT imaging
The subjects were intravenously injected with 99mTc labeled FAPI imaging agent, and drank 300-500ml of water after administration. SPECT-CT imaging was performed 60 minutes later
Sponsors & Collaborators
-
Nanjing First Hospital, Nanjing Medical University
lead OTHER
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-06-01
- Primary Completion
- 2026-01-31
- Completion
- 2026-05-31
Countries
- China
Study Locations
More Related Trials
-
A Novel 68Ga Labeled FAP Ligand PET/CT in Patients With Various Malignant Tumors
NCT06186427 ·Status: RECRUITING ·Phase: NA
-
FAP PET/CT or PET/MR Production in the Diagnosis, Staging, and Efficacy Assessment of Malignant Tumors Application
NCT06270394 ·Status: COMPLETED ·Phase: NA
-
68Ga-DOTA-NI-FAPI04 PET/CT in Patients With Various Types of Cancer
NCT06455761 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Exploring the Application Value of PET Molecular Imaging Targeting FAP in Oral Squamous Cell Carcinoma
NCT05030597 ·Status: RECRUITING
-
Application of FAPI and FDG PET Imaging in Patients With Different Types of Cancer
NCT06284070 ·Status: RECRUITING
-
68Ga-FAP-CHX PET/CT : Dosimetry and Preliminary Clinical Translational Studies
NCT05506566 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Clinical Application of 99mTc-FDPH46 SPECT/CT Imaging in Malignant Solid Tumor: a Prospective Exploratory Study
NCT06753513 ·Status: NOT_YET_RECRUITING
-
Diagnosis of Metastatic Tumors on 68Ga-FAPI PET-CT and Radioligand Therapy with 177Lu-EB-FAPI
NCT05400967 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Head-to-head Comparison of Positron Nuclide Radio-labeled FAPI and 18F-FDG PET/CT in Patients With Malignant Tumors
NCT06182644 ·Status: RECRUITING ·Phase: NA
-
Diagnosis of Metastatic Tumors on 68Ga-FAPI-RGD PET-CT and Radioligand Therapy With 177Lu-FAPI-RGD
NCT06638034 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Comparison of 68Ga-DOTA-FAPI-46 and 68Ga-DOTA-2P(FAPI)2 PET/CT in Patients With Various Types of Cancer
NCT04941872 ·Status: COMPLETED ·Phase: NA
-
18F-FDG PET/CT Guided Reduced-dose Radiotherapy for Nasopharyngeal Carcinoma
NCT04813705 ·Status: RECRUITING ·Phase: PHASE2
-
18F-FAPI-RGD PET/CT in Various Tumor Types
NCT06094530 ·Status: RECRUITING
-
18F-FAPI and 18F-FDG PET/CT in Patients With Various Types of Cancer
NCT05485792 ·Status: UNKNOWN ·Phase: NA
-
Tracer Targeting FAP PET Imaging in Patients
NCT05691894 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
68Ga-NI-FAPI PET/CT: First-in-human Study
NCT06688305 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
68Ga-FAPI-RGD PET/CT for Dual Integrin αvβ3 and FAP-targeted Imaging in Patients With Various Types of Cancer and Compared With 18F-FDG
NCT05543317 ·Status: COMPLETED ·Phase: NA
-
68Ga-FAP-RGD PET/CT : Dosimetry and Preliminary Clinical Translational Studies
NCT05515783 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Imaging of Solid Tumors Using FAP-2286
NCT04621435 ·Status: RECRUITING ·Phase: PHASE1
-
Clinical Study of Trap (FAPI) 3 PET Imaging in Noninvasive Diagnosis of Malignant Tumors
NCT07128277 ·Status: NOT_YET_RECRUITING
-
A Head-to-head Comparison of [68Ga]Ga-FAPI and [68Ga]Ga-TATE PET/CT in Patients With Nasopharyngeal Carcinoma: a Single-center, Prospective Study
NCT05990998 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
18F-AlF-FAPi-04 PET/CT Imaging in Patients With Solid Tumor
NCT06126705 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
68Ga-FAPI PET/CT in Patients With Various Types of Cancer
NCT04499365 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Clinical Study of 18F-FAPI-RGD in Breast Tumors
NCT05976620 ·Status: COMPLETED
-
Evaluation Using FAPI-PET Targeting Cancer-associated Fibroblasts
NCT05442151 ·Status: RECRUITING ·Phase: NA