Cannabinoids and Biological Reactivity to Stress

Summary

The goal of this study is to test the impact of two drugs that produce temporary stress-like symptoms, both in isolation and together, on cannabis use motivation in individuals with Cannabis Use Disorder. The main questions it will answer are:

1. How do different forms of stress affect cannabis use motivation?
2. How do different forms of stress affect the body's natural cannabinoids?

Researchers will compare a placebo to both drugs in isolation, as well as together, across four separate lab visits.

Participants will:

1\) Complete a clinical screening interview (by phone or in-person) and visit the lab for a medical screening, and if eligible:

a) Visit the lab four times where they will: i). Take one of four drug combinations ii). Complete an interview, questionnaires, and computerized tasks iii). Have their brain activity recorded with an EEG cap iv). Provide three blood samples

Conditions

• Cannabis Use Disorder

Interventions

DRUG

Hydrocortisone Oral

20mg hydrocortisone, single oral dose

DRUG

Yohimbine Hydrochloride

54mg yohimbine hcl, single oral dose

DRUG

Cornstarch Placebo 20mg

20mg cornstarch placebo, single oral dose

DRUG

Cornstarch Placebo 54mg

54mg cornstarch placebo, single oral dose

Sponsors & Collaborators

• Wayne State University

  collaborator OTHER

• National Institute on Drug Abuse (NIDA)

  collaborator NIH

• Auburn University

  collaborator OTHER

• Florida State University

  lead OTHER

Principal Investigators

• Richard J Macatee, PhD · Florida State University

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-09-30

Primary Completion

2026-09-30

Completion

2026-09-30

FDA Drug

Yes

Countries

• United States

Study Locations