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Study of VEGF-A Targeting NIR-II Fluorescence Endoscopy in the Gastrointestinal Tract

NCT06430372 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-05-13

No results posted yet for this study

Summary

In this study, the investigators are studying new ways to look for abnormal tissues of the gastrointestinal tract during an endoscopy. We are using a VEGF-A targeting fluorescent probe and a NIR-II fluorescent endoscope to help detect abnormal tissues that are hard to see by the naked eye.

The main purposes of this study include:

1. To translate the NIR-II approach into the endoscopy, and understand its advantages and limitations on detecting abnormal tissues in gastrointestinal.
2. To validate whether topical administration of a targeting probe can stick to abnormal tissues and be detected by the NIR-II endoscope.
3. To validate the safety and effectiveness of the topical administration of VEGF-A targeting probes for clinical application.

Conditions

  • Gastrointestinal Carcinoma
  • Dysplasia
  • Gastrointestinal Polyp

Interventions

DRUG

Bev-ICG

Probe targeting VEGF-A that is topically administrated during the endoscopy

DEVICE

NIR-II fluorescence endoscopy platform

An endoscopic detection device which can detect and visualize NIR-II fluorescent signal during the endoscopy

Sponsors & Collaborators

  • Institute of Automation, Chinese Academy of Sciences

    lead OTHER

Study Design

Allocation
NA
Purpose
SCREENING
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-20
Primary Completion
2025-05-30
Completion
2026-05-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06430372 on ClinicalTrials.gov