Expressions of Ezrin and Pip5k1α Proteins in Airway Smooth Muscle of Asthmatic Patients

Summary

Asthma, a prevalent chronic respiratory affliction, significantly impinges upon the quality of life for affected individuals. Timely and appropriate diagnostic measures, coupled with efficacious therapeutic interventions, are paramount in mitigating exacerbations of symptoms and enhancing the life quality of patients.

Ezrin plays an important role in maintaining cell morphology, cell migration, cell adhesion and polarisation, but Ezrin expression in airway smooth muscle remains unclear.

Pip5k1α is an important kinase involved in intracellular phosphatidylinositol signalling pathways that may be involved in smooth muscle contraction and diastole.

Therefore, further studies are necessary to elucidate the changes of Ezrin and Pip5k1α in patients with asthma to provide a basis for investigating alternative treatments for asthma.

Conditions

• Asthma
• Protein

Interventions

OTHER

No intervention.

Observational study with no intervention.

Sponsors & Collaborators

• Yueyang Hospital of Integrated Traditional Chinese and Western Medicine

  collaborator UNKNOWN

• Shanghai 6th People's Hospital

  collaborator OTHER

• Xiangya Hospital of Central South University

  collaborator OTHER

• Baoshan Hospital, Shanghai University of Traditional Chinese Medicine

  collaborator UNKNOWN

• Shanghai Pulmonary Hospital, Shanghai, China

  collaborator OTHER

• Lei-Miao Yin

  lead OTHER

Principal Investigators

• Lei-Miao Yin, MD · Yueyang Hospital, Shanghai University of Traditional Chinese medicine

• Wei-Wei He, MD · Shanghai 6th People's Hospital

• Jun-Tao Feng, MD · Xiangya Hospital of Central South University

• Li Li, MD · Baoshan Hospital, Shanghai University of Traditional Chinese Medicine

• Xiao-Ling Xu, MD · Shanghai Pulmonary Hospital, Tongji University

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-05-28

Primary Completion

2026-12-31

Completion

2026-12-31

Countries

• China

Study Locations