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Autopsy and Photon Counting Computed Tomography to Evaluate Thromboses Related to Central Venous Catheters

NCT06417541 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 75

Last updated 2026-04-28

No results posted yet for this study

Summary

Central venous (CVC) is essential in modern healthcare but unfortunately associated with complications, including thrombosis. In a recently published study, it was showed that 12 out of 12 deceased patients had subclinical CVK-related thrombosis (Rockholt et al.). To shed light on this problem, the current studies were designed. In sub-study 1, deceased patients with CVC who are referred for clinical autopsy are included. Before the autopsy, the deceased will be examined with a photon-counting computed tomography (CT) scan and the results will be compared.

In sub-study 2, living patients with CVC who are referred for various CT scans without contrast, are included. After informed consent, the patient will be examined with the photon-counting CT, whose reliability has been validated in Part 1 and the incidence of subclinical CVC-related thrombosis will be reported.

Conditions

  • Central Venous Catheter Thrombosis

Interventions

DIAGNOSTIC_TEST

Diseased patients with an indwelling central venous catheter who is referred to autopsy

Photon counting CT is performed and the results are compared to the results of the autopsy

RADIATION

Living patients with an indwelling central venous catheter referred to a CT scan without iv contrast

Patients will be investigated using a photon counting CT. Prior to the investigation patients will be investigated with ultrasound. The results from the two modalities will be compared

Sponsors & Collaborators

  • Thomas Kander

    lead OTHER

Principal Investigators

  • Thomas Kander · Lund University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-01-16
Primary Completion
2027-06-30
Completion
2028-06-30

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06417541 on ClinicalTrials.gov