Efficacy and Safety of Local Glucocorticoids for the Treatment of Acute Radiation-Induced Intestinal Injury

Summary

Due to the increasing number and prolonged survival of malignant tumor patients treated with radiotherapy, the complication, such as acute radiation-induced intestinal injury, has become increasingly significant. Glucocorticoids may play a therapeutic role by regulating the inflammatory response in patients with acute radiation-induced intestinal injury. However, the conclusions of related studies were controversial.

Conditions

• Radiation-Induced Intestinal Injury

Interventions

DRUG

Dexamethasone

Retention enema with 10mg dexamethasone, once a day, the total course of treatment for 1 week.

DRUG

Antibiotics, probiotics, vitamins, antidiarrheal drugs, enteral nutrition, and endoscopic argon plasma coagulation

Treatment according to guideline of radiation-induced intestinal injury.

Sponsors & Collaborators

• General Hospital of Shenyang Military Region

  lead OTHER

Principal Investigators

• Xingshun Qi · The General Hospital of Northern Theater Command

• Xiaofeng Liu · The 960th Hospital of the Chinese People's Liberation Army

• Xiaohua Bao · The 964th Hospital of the Chinese People's Liberation Army

• Cheng Bai · The 967th Hospital of the Chinese People's Liberation Army

• Junchen Ge · The 962rd Hospital of the Chinese People's Liberation Army

• Dongshuai Su · The 963rd Hospital of the Chinese People's Liberation Army

• Wenda Xu · The 81th Group Military Hospital of of the Chinese People's Liberation Army

• Ran Jiang · The 966th Hospital of the Chinese People's Liberation Army

• Yumei Hou · 92493 Hospital of the Chinese People's Liberation Army

• Hong Dai · Liaoning Provincial Corps Hospital of the Chinese People's Armed Police

• Bingguo Piao · The 78th Group Military Hospital of the Chinese People's Liberation Army

• Yufeng Zhang · The 79th Group Military Hospital of of the Chinese People's Liberation Army

• Lichun Shao · Air Force Hospital of Northern Theater Command

• Haijun Liang · 96605 Hospital of the Chinese People's Liberation Army

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-08-01

Primary Completion

2026-12-31

Completion

2026-12-31

Countries

• China

Study Locations