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Cardiac-Control Affecting Learning Through Mindfulness (CALM)

NCT06410157 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 240

Last updated 2026-05-13

No results posted yet for this study

Summary

Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily mindfulness practice with heart rate biofeedback during breathing in a pattern that either increases or decreases heart rate oscillation affect attention and memory and blood biomarkers associated with Alzheimer's disease.

Conditions

Interventions

BEHAVIORAL

Daily practice

Participants will be asked to undergo daily mindfulness practice while regulating (either increase or decrease) heart rate oscillation.

Sponsors & Collaborators

  • University of California, Irvine

    collaborator OTHER

  • National Institute on Aging (NIA)

    collaborator NIH

  • University of Southern California

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-14
Primary Completion
2027-11-30
Completion
2027-11-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06410157 on ClinicalTrials.gov