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Chronic Lung Allograft Dysfunction MRI Study

NCT06406777 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-03-27

No results posted yet for this study

Summary

This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if novel MRI imaging can serve as an objective confirmatory diagnostic tool for CLAD in post-transplant patients.

Conditions

  • Chronic Lung Allograft Dysfunction Lung MRI (CLAD)

Interventions

DIAGNOSTIC_TEST

Spirometry

Spirometry measures lung function, specifically the amount and/or speed of air that can be inhaled and exhaled.

DIAGNOSTIC_TEST

Contrast Lung Computed Tomography (CT) Scan

CT scan of the lungs using contrast

DIAGNOSTIC_TEST

Oxygen enhanced magnetic resonance imaging (OE-MRI) Scan

MRI will be taken while subject is lying on their back breathing 100% oxygen.

DRUG

129Xe MRI scans

MRI will be taken while subject is lying on their back breathing room oxygen and taking a breath of 129Xe and holding it for a few seconds.

Sponsors & Collaborators

  • Sean Fain

    lead OTHER

Principal Investigators

  • Sean Fain, Ph.D · University of Iowa

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-03-20
Primary Completion
2028-09-30
Completion
2028-09-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06406777 on ClinicalTrials.gov