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Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina

NCT06400290 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2025-06-06

No results posted yet for this study

Summary

ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery disease. This study will investigate the symptoms conferred by each stenosis, induced by experimental ischaemia, for 60 patients with multi-vessel coronary artery disease.

Conditions

  • Stable Angina
  • Multivessel Coronary Artery Disease

Interventions

PROCEDURE

Percutaneous coronary intervention (PCI)

Coronary artery stenting for stable angina

DIAGNOSTIC_TEST

Symptom assessment during experimentally induced ischaemia

Transient experimental balloon occlusion across coronary stenosis to determine the symptoms conferred by ischaemia at this stenosis.

Sponsors & Collaborators

  • Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust

    collaborator OTHER_GOV

  • Mid and South Essex NHS Foundation Trust

    collaborator OTHER

  • Imperial College Healthcare NHS Trust

    collaborator OTHER

  • St George's Healthcare NHS Trust

    collaborator OTHER

  • Royal Free Hospital NHS Foundation Trust

    collaborator OTHER

  • Imperial College London

    lead OTHER

Principal Investigators

  • Rasha Al-Lamee, PhD MRCP · Imperial College London

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-06-13
Primary Completion
2027-01-31
Completion
2027-04-30

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06400290 on ClinicalTrials.gov