MedTrace Logo

The Role of Red Cell Characteristics, Angiogenesis, Viscosity and Oxygenation in the Pathophysiology of Sickle Cell Related Retinopathy

NCT06396403 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 68

Last updated 2024-11-15

No results posted yet for this study

Summary

Objective:

to gain insight in the pathogenesis, to identify biomarkers to recognize patients at risk for proliferative SCR and to investigate its associations with clinical and laboratory characteristics.

Endpoints:

The investigators will determine the difference in the above named parameters between patients with and without PSCR

Study design:

This case control study will include adult sickle cell disease patients with the HbSS or HbSC genotype. For both genotypes, 20 patients without sickle cell retinopathy (SCR) and 20 patients with PSCR will be included, resulting in a total of 80 patients. Venous blood samples and retinal imaging scans will be collected for each included patient.

Conditions

Interventions

OTHER

Collection of venous blood samples

collection includes 1 EDTA tube and 1 Sarstedt S-Monovette tube of 5 mL

Sponsors & Collaborators

  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

    lead OTHER

Principal Investigators

  • Bart J Biemond, MD PhD · Department of Hematology, Amsterdam UMC, Amsterdam, The Netherlands

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-06-13
Primary Completion
2024-06-17
Completion
2024-06-17

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06396403 on ClinicalTrials.gov