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Building Research With Artificial Intelligence in Neuro-Ophthalmology

NCT06390579 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 693

Last updated 2025-09-08

No results posted yet for this study

Summary

The research team, recognized as a world leader in Artificial Intelligence for neuro-ophthalmology, has shown that it is possible to diagnose certain neuro-ophthalmologic or neurologic disorders from a single retinal fundus image (Milea et al, New England Journal of Medicine, 2020). However, clinical practice requires identifying a broader spectrum of diseases (inflammatory, ischemic, hereditary, neurodegenerative) within the same analysis.

The main objective is to develop, through a new algorithm capable of classifying multiple disorders from a smaller set of conventional retinal images.

This project meets a significant public health need: the global shortage of neuro-ophthalmologists. It aims to provide healthcare professionals with a rapid triage tool to detect serious and treatable conditions, enabling timely intervention.

The study will include patients with clearly defined neuro-ophthalmologic or neurologic conditions, confirmed diagnoses, and retinal imaging. Clinical, paraclinical, and imaging data collected during standard care will be used, with strict anonymization according to legal and institutional requirements.

Specific Objectives :

1. Evaluate the performance of a diagnostic classification algorithm trained on retinal images.
2. Assess the ability to detect multiple pathologies from a single retinal image.
3. Support the development of advanced computer vision tools for medical diagnostics.

Conditions

  • Optic Neuropathy
  • Optic Neuropathy, Ischemic
  • Optic Neuritis
  • Optic Nerve Diseases
  • Papilledema
  • Optic Atrophy
  • Brain Tumors
  • Retinal Photograph
  • Artificial Intelligence (AI)
  • Machine Learning
  • Deep Learning

Interventions

OTHER

Deep learning algorithm applied on retrospectively collected color fundus photographs

Deep learning algorithm applied on retrospectively collected color fundus photographs

Sponsors & Collaborators

  • Fondation Ophtalmologique Adolphe de Rothschild

    lead NETWORK

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-10-01
Primary Completion
2024-02-01
Completion
2024-02-01

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06390579 on ClinicalTrials.gov