MedTrace Logo

London Asthma Diagnostics Study

NCT06383130 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 225

Last updated 2024-04-25

No results posted yet for this study

Summary

The goal of this trial is to learn if the addition of oscillometry with reversibility testing increases diagnostic accuracy in adult asthma diagnosis, when added to current standard of care tests: spirometry with reversibility testing and Fractional Exhaled Nitric Oxide (FeNO). The main question it aims to answer is:

\- Does oscillometry with reversibility testing increase diagnostic accuracy in detection of asthma in adults when added to spirometry with reversibility and FeNO?

Researchers will evaluate the diagnostic accuracy of this approach with the reference standard, which is a clinically adjudicated diagnosis of asthma by two respiratory clinicians based on history and investigation results.

Participants will

* Undergo oscillometry testing alongside their routine asthma investigations within their scheduled clinic visit
* Optionally participate in our sub-studies on new breath and nasal swab tests for asthma
* Optionally participate in our qualitative substudy on patients views and attitudes to asthma testing and oscillometry

Conditions

Interventions

DIAGNOSTIC_TEST

Oscillometry with reversibility testing

Oscillometry is a test that uses sound waves to measure the mechanical properties in the lungs during tidal breathing

DIAGNOSTIC_TEST

Breath volatile testing

We will be optimising and evaluating the sensitivity and specificity of a novel breath volatile organic compound test of a combination of reactive aldehydes using a gas chromatography-ion mobility spectrometry device

DIAGNOSTIC_TEST

Nasal eosinophil peroxidase

We will be evaluating the sensitivity and specificity of a novel nasal swab test for eosinophil peroxidase

DIAGNOSTIC_TEST

Handheld capnometry

We will be evaluating handheld capnometry (carbon dioxide breath testing) to diagnose adult asthma

Sponsors & Collaborators

  • Asthma UK

    collaborator OTHER

  • General Practitioners Research Institute

    collaborator NETWORK

  • Imperial College London

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-06-30
Primary Completion
2025-12-31
Completion
2026-07-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06383130 on ClinicalTrials.gov