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Asthma: Phenotyping EXacerbations

NCT04293588 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2021-04-29

No results posted yet for this study

Summary

The main outcomes of this study are to establish a cohort of well-phenotyped asthma patients with a recent history of an exacerbation. We aim to describe exacerbation profiles (phenotypes) of the cohort in terms of inflammatory/biomarker profile and bacterial/viral infection status and to compare these with exacerbation events in the sister APEX cohort.

Conditions

Interventions

DIAGNOSTIC_TEST

spirometry, FOT, Induced sputum, bloods, nasal brushes, nasal lavage, skin prick, throat swab

At the point of baseline visit, exacerbation and annual visit, the above tests will be performed to allow comparison of a participants profile before and during an exacerbation

Sponsors & Collaborators

  • AstraZeneca

    collaborator INDUSTRY

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Tim rofessor Harrison, MBBS, BSc, FRCP, MD, MSc · University of Nottingham

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-11-22
Primary Completion
2022-07-31
Completion
2022-07-31

Countries

  • United Kingdom

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04293588 on ClinicalTrials.gov