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Comparative Evaluation of Melatonin Versus MTA on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study

NCT06372561 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2024-08-02

No results posted yet for this study

Summary

The process of dental caries is dynamic and can be either reversible or irreversible depending on the balance between protective and pathologic factors in the oral cavity. Untreated dental caries causes pulpal injury, inflammation, and necrosis. Melatonin plays an essential role in the regulation of bone growth. The actions that melatonin exerts on odontoblasts may be similar to its action on osteoblasts.

Conditions

  • Dental Caries in Children
  • Vital Pulp Therapy

Interventions

DRUG

Mineral trioxide aggregate (dressing material)

MTA (Angulus Industrial de productus Odontologists S/a, Brazil) that applied on dental pulp for tissue regeneration

DRUG

Melatonin (dressing material)

melatonin powder 250mg (sigma, Aldrich)- white powder mixing with saline and applied on dental pulp

Sponsors & Collaborators

  • Suez Canal University

    lead OTHER

Principal Investigators

  • Gihan GED El-Desouky, Professor · Professor

  • Ghada AH Elbaz, Professor · Professor

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
6 Years
Max Age
8 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-05-20
Primary Completion
2024-09-20
Completion
2024-10-02

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06372561 on ClinicalTrials.gov