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Radiotherapy vs Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease

NCT06360939 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-02-18

No results posted yet for this study

Summary

The goal of this randomized clinical trial is to test the efficacy of stereotactic body radiation therapy (SBRT) in treating ventricular tachycardia (VT) in patients with advanced structural heart disease. The main questions it aims to answer are:

* What is the efficacy of SBRT compared to catheter ablation (CA) in achieving a ≥ 75% reduction in VT burden at 6 months
* What is the comparable safety profile of SBRT vs CA Researchers will compare SBRT and CA (standard of care).

Conditions

  • Ventricular Tachycardia
  • Cardiomyopathies
  • Arrhythmias, Cardiac
  • Ventricular Arrythmia

Interventions

RADIATION

SBRT

Delivery of 25Gy in a single dose fraction to target area within 6 weeks of randomization

PROCEDURE

CA

CA (endocardial and/or epicardial at operator discretion) within 6 weeks of randomization.

Sponsors & Collaborators

  • University of Sydney

    collaborator OTHER

  • National Heart Foundation, Australia

    collaborator OTHER

  • Western Sydney Local Health District

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-03
Primary Completion
2026-06-20
Completion
2027-12-20

Countries

  • Australia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06360939 on ClinicalTrials.gov