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Polymorphisms in ENAM, AMBN, and KLK4 Contribute to DCS.

NCT06343766 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 204

Last updated 2024-04-03

No results posted yet for this study

Summary

A Cross-Sectional Study aims to shed light on potential genetic determinants influencing dental caries susceptibility within this demographic and significantly understanding of genetic factors associated with dental caries, particularly within the context of the Egyptian population, providing valuable insights into the genetic aspects of oral health. The research methodology involved a comprehensive examination of these polymorphic loci ENAM, AMBN, TUFT1 and KLK4 and their prevalence, employing rigorous statistical analyses to establish potential correlations between these genetic variants and susceptibility to dental caries.

Conditions

  • Dental Caries Secondary to Polymorphisms
  • Polymorphisms in Enamel Encoding Genes

Interventions

GENETIC

DNA collation and genotyping

DNA collation and genotyping of specific genes ENAM rs3796703, AMBN rs4694075), TUFT1 rs78802584 and KLK4 rs2242670 through PCR and sequencing for various SNPs Dental examinations by comparing dental covariates such as the number of DMF-T index, presence of biofilm, gingivitis, fluorosis, and detection of interproximal caries with caries progression.

Sponsors & Collaborators

  • Amina Fouad Farag

    lead OTHER

Principal Investigators

  • Hassan M. Negm, PhD · Faculty of Dentistry, October 6 University, Giza, Egypt; +201222323200; [email protected]

  • Rania R. Omar, PhD · Faculty of Dentistry, October 6 University, Giza, Egypt; [email protected]

  • Amina F. Farag, PhD · Faculty of Dentistry, October 6 University, Giza, Egypt; [email protected]

Eligibility

Min Age
15 Years
Max Age
22 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-11-06
Primary Completion
2023-11-05
Completion
2023-11-05

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06343766 on ClinicalTrials.gov