INOCA Spanish National Registry

Summary

Coronary atherosclerosis is the most common cause of ischaemic heart disease. About 40-50% of patients with symptoms and documented ischaemia on non-invasive tests do not show obstructive coronary artery disease on coronary angiography. This cause of ischaemic heart disease called INOCA (Ischemic Non-Obstructive Coronary Artery), far from having a benign prognosis, is associated with an increase in major adverse cardiac events (MACE) as well as increased functional limitation. The current European Society of Cardiology clinical practice guidelines for the management of chronic coronary syndrome establish for the first time a IIa recommendation for the invasive analysis of coronary flow reserve (CFR) and microvascular resistance index (MRI) in symptomatic patients with INOCA. The acetylcholine (Ach) test, based on intracoronary (ic) administration, is established as indication IIb for the assessment of micro or macrovascular vasospasm in patients with suspected vasospastic angina (VSA) (4). A national multicentre registry would allow us to determine the prevalence of INOCA and its different endotypes in our setting.

Conditions

• Non-Obstructive Coronary Atherosclerosis
• Ischemia
• Coronary Disease

Sponsors & Collaborators

• Hospital San Carlos, Madrid

  collaborator OTHER

• Fundación de Investigación Biomédica - Hospital Universitario de La Princesa

  collaborator OTHER

• Hospital Universitario Virgen de la Arrixaca

  collaborator OTHER

• University Hospital Gregorio Marañón

  collaborator OTHER

• Hospital Clínico Universitario de Valladolid

  collaborator OTHER

• Hospital Universitario Puerta del Mar

  collaborator OTHER

• Hospital Universitari de Bellvitge

  collaborator OTHER

• Hospital Universitario La Fe

  collaborator OTHER

• Hospital Clínico Universitario de Valencia

  collaborator OTHER

• Hospital Universitario La Paz

  collaborator OTHER

• Hospital General Universitario de Alicante

  collaborator OTHER

• Complejo Hospitalario Universitario de Huelva

  collaborator OTHER

• Hospital General Universitario de Castellón

  collaborator OTHER

• Hospital de Manises

  collaborator OTHER

• Hospital Clinic of Barcelona

  collaborator OTHER

• Hospital Miguel Servet

  collaborator OTHER

• Hospital Clínico Universitario Lozano Blesa

  collaborator OTHER

• Hospital Donostia

  collaborator OTHER

• Hospital General Universitario Elche

  collaborator OTHER

• Hospital Universitario Virgen del Rocio

  collaborator UNKNOWN

• Hospital de la Ribera

  collaborator OTHER

• Hospital de la Santa creu i Sant Pau - Barcelona

  collaborator OTHER

• Hospital Virgen de la Salud

  collaborator OTHER

• Hospital Universitario San Juan de Alicante

  collaborator OTHER

• Hospital Universitario de Torrevieja

  collaborator UNKNOWN

• University Hospital of the Nuestra Señora de Candelaria

  collaborator OTHER

• Hospital de Basurto

  collaborator OTHER

• Hospital Universitario Ramon y Cajal

  collaborator OTHER

• Hospital Universitario Fundación Jiménez Díaz

  collaborator OTHER

• Puerta de Hierro University Hospital

  collaborator OTHER

• Hospital Universitario 12 de Octubre

  collaborator OTHER

• University of Salamanca

  collaborator OTHER

• Hospital Universitario Marqués de Valdecilla

  collaborator OTHER

• Hospital Clinico Universitario de Santiago

  collaborator OTHER

• Complexo Hospitalario Universitario de A Coruña

  collaborator OTHER

• Eva Rumiz González

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-03-24

Primary Completion

2025-03-31

Completion

2026-03-31

Countries

• Spain

Study Locations