GlycOxiTOD: Multimodal Vascular and Target-Organ Damage Registry

Summary

The goal of the GlycOxiTOD observational registry is to improve the early detection and characterization of vascular and other target-organ damage in adults at increased cardiovascular risk.

Target-organ damage (TOD) means changes in the arteries, heart, kidneys, or other organs that may develop before cardiovascular symptoms or events occur. The registry studies how blood pressure, arterial function, vascular imaging, metabolic and glycoxidative markers, and non-invasive optical signals are related to this early damage.

The main questions are:

* Which clinical, blood pressure, imaging, and laboratory markers are associated with vascular and other target-organ damage?
* Can photoplethysmography, a non-invasive optical technique that records changes in blood flow, identify abnormal arterial features?
* Are new devices, measurement procedures, and signal-analysis methods technically valid, reliable, and reproducible when compared with established clinical methods?
* Can combinations of clinical, imaging, laboratory, and device-derived measurements improve cardiovascular risk assessment?
* How do vascular abnormalities and target-organ damage change during follow-up?

Researchers will not assign any treatment as part of this observational registry. Participants will receive assessments that may include:

* Clinical and cardiovascular risk evaluation
* Office and 24-hour ambulatory blood pressure measurements
* Blood and urine tests for metabolic, glycation, oxidative stress, and inflammatory markers
* Non-invasive vascular ultrasound and arterial function measurements
* Optical photoplethysmography recordings from peripheral or cervical arterial sites
* Skin measurement of advanced glycation end products
* Retinal imaging, when available
* Repeated measurements to assess the reliability and reproducibility of selected devices and procedures
* Follow-up using clinical visits and medical records to identify changes in target-organ damage and cardiovascular events

The registry provides a shared clinical research platform for studies on hypertension, vascular imaging, arterial biomechanics, biomarkers, optical technologies, and the technical and methodological validation of non-invasive cardiovascular devices. Its overall aim is to support the development of reliable tools for early cardiovascular risk assessment and prevention.

Conditions

• Hypertension
• Target Organ Damage
• Heart Disease Risk Factors
• Vascular Stiffness
• Atherosclerosis

Interventions

DIAGNOSTIC_TEST

Multimodal Cardiovascular Phenotyping

Multimodal cardiovascular phenotyping may include clinical and anthropometric assessment; office and 24-hour ambulatory blood pressure monitoring; vascular ultrasound and arterial-function measurements; blood and urine biomarkers related to metabolism, glycation, oxidative stress, and inflammation; skin advanced glycation assessment; retinal imaging; and peripheral or cervical photoplethysmography. Selected measurements may be repeated to assess technical feasibility, agreement with reference methods, repeatability, reproducibility, and signal or image quality of non-invasive devices and analytical procedures. Assessments depend on the applicable protocol or nested study, and not all participants undergo every procedure.

Sponsors & Collaborators

• Sociedad Española De Medicina Interna

  collaborator OTHER

• Axencia Galega de Innovación (GAIN)

  collaborator UNKNOWN

• Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)

  collaborator UNKNOWN

• Complejo Hospitalario Universitario de Santiago

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-01-10

Primary Completion

2031-03-31

Completion

2035-12-31

Countries

• Spain

Study Locations