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Sparking Gut Bacteria Production of Bioactive Xenolipids in Situ

NCT06313606 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2026-05-11

No results posted yet for this study

Summary

Long-chain cyclopropane fatty acids (CpFAs) are microbially-derived lipids (fats), some of which can be found in select foods and appear to be produced naturally in the gut from dietary fatty acid precursors. Some of these lipids appear to have signaling properties in the body's tissues, i.e., to help regulate cardiometabolic health. Thus, increasing the bioavailability of CpFAs in humans may have utility to improve management of blood sugar and blood lipids, or to mitigate or prevent non-alcoholic fatty liver disease (NAFLD). This study is a proof-of-principle experiment in 10 subjects, to feed dietary fats thought to enhance upper gut CpFA production. The latter will be monitored through post-meal blood and urine CpFA concentration measurements, as well as concentration in the stool.

Conditions

  • Dietary Fat Metabolism

Interventions

DIETARY_SUPPLEMENT

Dietary fat positive control

Dietary fat-containing meal plan with a specific supplement that may modify fat metabolism

DIETARY_SUPPLEMENT

Dietary fat negative control

Dietary fat-containing meal plan with a specific supplement that should not modify fat metabolism

Sponsors & Collaborators

  • University of California, Davis

    lead OTHER

Principal Investigators

  • Sean H. Adams, PhD · University of California, Davis

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-05-21
Primary Completion
2024-08-26
Completion
2024-08-26

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06313606 on ClinicalTrials.gov