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Sphenopalatine Ganglion Block and Cold Induced Headaches

NCT06310200 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-01-31

No results posted yet for this study

Summary

The primary objective of this study is to determine if a sphenopalatine ganglion (SPG) block, performed through intranasal atomization of 4% lidocaine, is able to prevent cold induced cephalgia ("Brain Freeze"). Secondary objectives will be to determine the degree of decreased pain/duration of brain freeze after sphenopalatine ganglion block

Conditions

  • Cold Induced Headache
  • Brain Freeze
  • Cold Induced Cephalgia
  • Headache

Interventions

DRUG

Lidocaine Topical 4% Topical Solution

Intranasal administration

DRUG

Bitrex

Bittering agent

DRUG

normal saline

Placebo

Sponsors & Collaborators

  • Wright State University

    lead OTHER

Principal Investigators

  • Brian P Murray, DO · Wright State University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-01
Primary Completion
2025-05-01
Completion
2025-07-01
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06310200 on ClinicalTrials.gov