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Rapid Local Ischemic Postconditioning in Acute Ischemic Stroke

NCT06307743 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 135

Last updated 2024-03-13

No results posted yet for this study

Summary

The objective of this clinical trial is to determine whether rapid local ischemic postconditioning (RL-IPostC) is effective in preventing brain edema and safe in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy. In this trial, researchers will block antegrade cerebral blood flow temporarily by the way of balloon inflation/deflation in AIS patients immediately after revascularization. It makes the ischemic reperfusion brain tissue have a capacity of adaptation through intermittent blood flow restoration. Researchers will evaluate the protective role and safety of different duration of balloon inflation/deflation. The optimal postconditioning intervention dose will be determined for further confirmative investigation.

Conditions

  • Acute Ischemic Stroke
  • Mechanical Thrombectomy
  • Ischemic Postconditioning
  • Brain Edema

Interventions

PROCEDURE

rapid local ischemic postconditioning

Rapid local ischemic postconditioning (RL-IPostC) is performed immediately (within 5 minutes) after revascularization. A balloon guiding catheter (BGC) positioned on ipsilateral C1 segment of internal carotid artery is inflated and deflated for the temporary occlusion of the antegrade flow.

Sponsors & Collaborators

  • Zhangzhou Municipal Hospital of Fujian Province

    collaborator OTHER

  • Shanghai East Hospital

    collaborator OTHER

  • First People's Hospital of Hangzhou

    collaborator OTHER

  • RenJi Hospital

    collaborator OTHER

  • Shanghai Jiao Tong University Affiliated Sixth People's Hospital

    lead OTHER

Principal Investigators

  • Yueqi Zhu, MD · Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-03-15
Primary Completion
2025-06-15
Completion
2025-09-15

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06307743 on ClinicalTrials.gov