Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors

Summary

The goal of this observational study is to learn about long term symptoms in oesophageal cancer survivors. The main question it aims to answer is are:

* Study the changes in gut bacteria by examining saliva, stool and blood.
* Investigate the products of bacteria in breath to develop a non-invasive breath test to detect the changes in gut bacteria.
* Develop new strategies to treat this change and trial new treatments to improve quality- of-life in oesophageal cancer survivors.

Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath, saliva, blood, urine, stool and complete validated healthy-related quality-of-life questionnaires.

Researchers will compare symptomatic and asymptomatic participants to detect the changes stated above.

Conditions

• Oesophageal Cancer
• Quality of Life
• Bacterial Overgrowth

Interventions

DIAGNOSTIC_TEST

Breath test

Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath.

DIAGNOSTIC_TEST

Saliva sample

Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of saliva.

DIAGNOSTIC_TEST

Blood sample

Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of blood.

DIAGNOSTIC_TEST

Urine sample

Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of urine.

DIAGNOSTIC_TEST

Stool sample

Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of stool.

DIAGNOSTIC_TEST

Health-related Quality of life questionnaires

Participants will attend an outpatient clinic and complete validated healthy-related quality-of-life questionnaires.

Sponsors & Collaborators

• Imperial College Healthcare NHS Trust

  collaborator OTHER

• West Hertfordshire Teaching Hospitals NHS Trust

  collaborator UNKNOWN

• Barking, Havering and Redbridge University Hospitals NHS Trust

  collaborator OTHER

• Imperial College London

  lead OTHER

Eligibility

Min Age

18 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-03-09

Primary Completion

2025-10-01

Completion

2025-12-01

Countries

• United Kingdom

Study Locations