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The Effect of PRP on Wound Healing in High Risk Patients Undergoing Abdominal Hysterectomy

NCT06298110 · Status: NOT_YET_RECRUITING · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2024-03-08

No results posted yet for this study

Summary

To evaluate the effect of PRP on wound healing in high risk patients undergoing abdominal hysterectomy.

Conditions

  • Wound Heal
  • Abdominal Wound
  • PRP

Interventions

BIOLOGICAL

Platelets Rich plasma of the same patient

on the morning of surgery, 30 mL of venous blood will be drawn from the patient in anticoagulant-containing PRP tube for preparation of PRP solution. The drawn blood will be centrifuged at 1,200 rpm for 12 minutes to be separated into three layers: an upper layer that contains platelets and white blood cells, an intermediate thin layer (the buffy coat) that is rich in white blood cells, and a bottom layer that contains red blood cells. The upper and intermediate buffy layers will be transferred to an empty sterile tube. The plasma will be centrifuged again at 3,300 rpm for 7 minutes to help with the formation of soft pellets (erythrocytes and platelets) at the bottom of the tube. Pellets are homogenized in the lower third (5 mL) of the plasma to create the PRP. The prepared PRP solution will be transferred within sterile single use syringe (3cm) from the laboratory to the operation room, then applied and spread over the subcutaneous space before skin closure

Sponsors & Collaborators

  • Helwan University

    lead OTHER

Principal Investigators

  • Shimaa Bilal, Professor · Helwan University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-03-10
Primary Completion
2024-08-25
Completion
2024-09-25

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06298110 on ClinicalTrials.gov