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Analysis of Vitamin D and VDR Expression in Endometriosis: A Case-Control Study

NCT06289257 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 108

Last updated 2025-07-04

No results posted yet for this study

Summary

The goal of this cross-sectional prospective matching study is to evaluate whether serum vitamin D levels and vitamin D receptor (VDR) expression are associated with the presence and severity of endometriosis in women of reproductive age.

The main questions it aims to answer are:

* Is there a difference in serum 25-hydroxyvitamin D \[25(OH)D\] levels between women with endometriosis and healthy controls?
* Is there a correlation between serum vitamin D levels and VDR expression in endometriotic tissues?
* Is there an association between vitamin D status and the severity of endometriosis based on the revised American Society for Reproductive Medicine (rASRM) staging?

Researchers will compare participants with endometriosis to matched healthy controls (1:2 ratio).

Participants will:

* Provide blood samples for serum 25(OH)D measurement.
* Undergo surgical tissue sampling (for the endometriosis group) to assess VDR expression using immunohistochemistry staining.
* Complete structured questionnaires regarding sun exposure, lifestyle, and clinical characteristics.

Conditions

  • Endometriosis
  • Vitamin D Deficiency/Insufficiency
  • Vitamin D Status

Interventions

DIAGNOSTIC_TEST

Vitamin D level

Vitamin D level in blood

OTHER

Vitamin D receptor

Vitamin D receptor in endometriosis tissue

Sponsors & Collaborators

  • Khon Kaen University

    lead OTHER

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-05-06
Primary Completion
2024-12-23
Completion
2024-12-23

Countries

  • Thailand

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06289257 on ClinicalTrials.gov