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Metformin IN Asthma for Overweight and Obese Individuals (MINA)

NCT06273072 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-01-16

No results posted yet for this study

Summary

This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.

Conditions

  • Asthma
  • Asthma Chronic
  • Overweight and Obesity

Interventions

DRUG

Metformin hydrochloride extended-release tablets

titrated to 2000 mg once daily

DRUG

Visually identical placebo Metformin hydrochloride extended-release tablets

placebo

Sponsors & Collaborators

  • Baylor College of Medicine

    collaborator OTHER

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Temple University

    collaborator OTHER

  • Johns Hopkins University

    lead OTHER

Principal Investigators

  • Meredith C McCormack, M.D., M.H.S. · Johns Hopkins University

  • Tianshi D Wu, M.D., M.H.S. · Baylor College of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-09
Primary Completion
2026-09-30
Completion
2028-12-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06273072 on ClinicalTrials.gov