Is Long-Term Proton Pump Inhibitor Use a Cause of Leaky Gut Syndrome
NCT06268834 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 75
Last updated 2024-02-20
Summary
Our study aims to investigate the effect of bacterial overgrowth induced by long-term PPI use on zonulin levels.
Conditions
- Proton Pump Inhibitor Adverse Reaction
Interventions
- DIAGNOSTIC_TEST
-
Blood for zonulin level was drawn from the group.
Serum zonulin levels were determined by taking 5 cc blood from the antebrachial veins of the patients.
Sponsors & Collaborators
-
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- PREVENTION
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2023-10-04
- Primary Completion
- 2023-12-31
- Completion
- 2023-12-31
Countries
- Turkey (Türkiye)
Study Locations
More Related Trials
-
Oral vs Intravenous and Proton Pump Inhibitor (PPI)for Peptic Ulcer Bleeding (PUB)
NCT01123031 ·Status: WITHDRAWN ·Phase: PHASE4
-
Effect of Proton Pump Inhibitors on Gut Microbiota and Systemic Inflammation in Older Adults
NCT02844621 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Efficacy of Low Dose Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
NCT03814421 ·Status: UNKNOWN ·Phase: NA
-
Study Evaluating Pantoprazole in Peptic Ulcer Hemorrhage
NCT00037570 ·Status: COMPLETED ·Phase: PHASE2
-
Risk of Cancer Among Pantoprazole Users
NCT01322633 ·Status: COMPLETED
-
Proton Pump Inhibitor (PPI) Inappropriate Use and Economic Burden in Chinese Population
NCT03118778 ·Status: COMPLETED
-
The Clinical Significance of Acid Rebound in Functional Dyspepsia
NCT01373970 ·Status: TERMINATED ·Phase: PHASE4
-
To Learn How Bone Structure and Bone Mass Change After Long-term PPI Use
NCT01306799 ·Status: COMPLETED
-
Fundic Gland Polyps and Proton Pump Inhibitor (PPI) Drugs
NCT01130363 ·Status: TERMINATED
-
A Study to Evaluate the Effect of Food, Formulation, and a Proton Pump Inhibitor (PPI) on Calderasib (MK-1084) in Healthy Adult Participants (MK-1084-003)
NCT06619314 ·Status: COMPLETED ·Phase: PHASE1
-
Treatment of Zollinger-Ellison Syndrome With Prevacid
NCT00204373 ·Status: COMPLETED ·Phase: PHASE4
-
Trial of Oral Versus Intravenous Proton Pump Inhibitor on Intragastric pH in Patients With Bleeding Ulcers
NCT00573924 ·Status: COMPLETED ·Phase: NA
-
A Study to Investigate the Effect of Increased Gastric pH on the Oral Bioavailability of the Orexin-2 Receptor Antagonist JNJ-42847922 in Healthy Participants
NCT02475161 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of Proton Pump Inhibitors on Endothelial Function
NCT02022280 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Breath Testing for Small Intestinal Bacterial Overgrowth
NCT05976165 ·Status: RECRUITING ·Phase: NA
-
PPI Test in GP Patients
NCT00318084 ·Status: COMPLETED ·Phase: PHASE4
-
Optimal Dose of Proton Pump Inhibitors Following an Upper Gastrointestinal Bleed
NCT02235311 ·Status: TERMINATED ·Phase: NA
-
Should I Continue Taking My Acid Reflux Medication? Development and Pilot Testing of a Patient Decision Aid
NCT02558049 ·Status: COMPLETED ·Phase: NA
-
The Efficacy of Pantoprazole Treatment in Patients With Functional Dyspepsia
NCT01608750 ·Status: UNKNOWN ·Phase: PHASE4
-
EffCaMgCit to Prevent Mineral Metabolism and Renal Complications of Chronic PPI Therapy
NCT05998863 ·Status: RECRUITING ·Phase: PHASE3
-
Comparison of Proton Pump Inhibitor and H2 Receptor Blocker on Prevention of Bleeding From Iatrogenic Ulcer After Endoscopic Submucosal Dissection for Gastric Neoplasms: A Prospective Randomized Controlled Trial
NCT01179724 ·Status: UNKNOWN ·Phase: NA
-
13-C Urea Breath Test Using BreathID System and PPIs (Proton Pump Inhibitors)
NCT00825630 ·Status: COMPLETED ·Phase: PHASE4
-
Gastric pH in Critically Ill Patients
NCT00590928 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy of Proton Pump Inhibitor in Prevention of Clopidogrel-related Peptic Ulcer
NCT01138969 ·Status: COMPLETED ·Phase: PHASE2
-
Gastric Functions & Proton Pump Inhibitor( PPI) Study
NCT00951431 ·Status: COMPLETED ·Phase: PHASE4