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Alcohol After Bariatric Surgery 2

NCT06257771 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 88

Last updated 2025-03-11

No results posted yet for this study

Summary

The goal of this observational study is to learn how the body processes ingested alcohol and how alcohol affects mood and blood sugar in both men and women after undergoing sleeve gastrectomy. The main question\[s\]it aims to answer are:

* Are there differences in the way that ingested alcohol is handled in men versus women after sleeve gastrectomy?
* What is the consequence of drinking alcohol on an empty stomach versus after a meal on blood sugar control after undergoing sleeve gastrectomy?

Participants will participate in two types of alcohol tests (alcohol given orally or administered intravenously) after not eating anything overnight or after having a meal.

Researchers will compare men and women who underwent sleeve gastrectomy with men and women who had no surgery, are of similar age and body composition, and have similar alcohol intake patterns.

Conditions

  • Sleeve Gastrectomy

Interventions

DRUG

Alcohol (Ethanol)

Alcohol given orally (0.5 grams of alcohol per kg of fat-free mass) Alcohol given iv with a clamp ( 6% v/v alcohol prepared in 0.5% normal saline). The infusion rate will exponentially increase from the start of the infusion until the target BrAC of 0.6g/L (60mg%) is reached at 15 min, followed by an exponentially decreasing infusion rate, which will be tapered to a constant steady-state value to clamp the BrAC at the target value for a predetermined duration of 180 min.

Sponsors & Collaborators

  • Carle Foundation Hospital

    collaborator OTHER

  • University of Illinois at Urbana-Champaign

    lead OTHER

Principal Investigators

  • Marta Y Pepino de Gruev, PhD · University of Illinois at Urbana-Champaign

Eligibility

Min Age
21 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-07-31
Primary Completion
2028-07-31
Completion
2028-08-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06257771 on ClinicalTrials.gov