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Live Vaccines and Innate Immune Training in COPD.

NCT06257212 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-03-19

No results posted yet for this study

Summary

A randomized, single-blinded clinical pilot study to assess whether vaccination with live attenuated vaccines can induce trained immunity and cause beneficial changes in patients with COPD.

Conditions

  • Trained Innate Immunity
  • COPD

Interventions

DRUG

BCG vaccine (Danish strain 1331)

Intradermal BCG vaccine (0.1 ml) + subcutaneous saline at inclusion and after 3 months.

DRUG

MMR Vaccine

Subcutaneous MMR vaccine (0.5ml) + intradermal saline at inclusion and after 3 months.

DRUG

Placebo

Subcutaneous saline + intradermal saline at inclusion and after 3 months.

Sponsors & Collaborators

  • Josefin Eklöf

    lead OTHER

Principal Investigators

  • Jens-Ulrik Stæhr S Jensen, MD,Phd · Herlev Gentofte Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
SINGLE_GROUP

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-02-28
Primary Completion
2025-08-25
Completion
2025-08-25

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06257212 on ClinicalTrials.gov