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Persistent Pain After Cesarean Delivery - A Danish Multicenter Cohort Study

NCT06247852 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 477

Last updated 2025-09-03

No results posted yet for this study

Summary

In Denmark, around 12,700 patients undergo Cesarean delivery (CD) annually, constituting approximately 20% of all childbirths in the country. Worldwide, the number is increasing each year, with more than 20 million CD performed annually.

Postoperative pain after CD is typically moderate to severe in intensity and still constitutes a significant challenge, balancing effective pain relief and potential side effects. Correlations between moderate to severe acute pain and the development of persistent pain after CD is still unclear.

Postsurgical persistent pain is a significant, often unrecognized clinical problem that causes distress and diminishes the quality of life for patients. Despite advances in understanding the factors contributing to persistent postsurgical pain and an increased focus on identifying patients at risk, the management and prevention of postsurgical persistent pain are still inadequate.

It is important to gain further insights into this population, and we have a unique opportunity to do so by following the national cohort from the ongoing Danish multicenter cohort study on pain after cesarean section (ClinicalTrials.gov Identifier: NCT06012747) over an extended follow-up period.

This involves continued prospective registration of Patient-Reported Outcome Measures (PROM) collected by SMS-based questionnaires in the months and years after the CD, thereby investigating the occurrence of both acute and persistent pain after CD.

The outcomes are focused on pain levels, the impact of pain on physical function and neuropathic pain characteristics in the months and years following the CD. The study also aims to explore the relationship between persistent and acute pain.

Conditions

  • Cesarean Section Complications
  • Cesarean Section
  • Cesarean Delivery
  • Persistent Pain
  • Chronic Pain
  • SMS
  • Questionnaire

Sponsors & Collaborators

  • Nordsjaellands Hospital

    lead OTHER

Principal Investigators

  • Patricia Duch, MD · University Hospital of Copenhagen, Hillerød, Denmark

  • Helene Nedergaard, MD, Ph.D · University Hospital of Southern Denmark, Kolding

  • Christoffer Jørgensen, Dr. Med. · University Hospital of Copenhagen, Hillerød, Denmark

  • Kim Wildgaard, MD, Ph.d. · University Hospital of Copenhagen, Herlev, Denmark

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-01
Primary Completion
2025-06-10
Completion
2025-09-01

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06247852 on ClinicalTrials.gov