Effect of HIgh-flow Therapy in Long-term Oxygen Therapy

Summary

This is a registry-based, randomized, controlled clinical trial of the effect of added high-flow oxygen therapy (using the device Lumis HFT) during one year in people with long-term oxygen therapy (LTOT) for chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD).

Conditions

• Chronic Obstructive Pulmonary Disease Severe
• Interstitial Lung Disease
• Chronic Respiratory Failure With Hypoxia

Interventions

DEVICE

Added high-flow oxygen therapy

Added high-flow oxygen therapy using the device Lumis HFT during nighttime and at the patient's discretion daytime, with the usual care (low-flow oxygen therapy) the rest of the time.

OTHER

Standard care

Standard care with low-flow oxygen therapy in accordance with clinical routine.

Sponsors & Collaborators

• Uppsala University Hospital

  collaborator OTHER

• Region Stockholm

  collaborator OTHER_GOV

• Region Örebro County

  collaborator OTHER

• Blekinge County Council Hospital

  collaborator OTHER

• Blekinge Institute of Technology

  collaborator OTHER

• Lund University

  collaborator OTHER

• Region Östergötland

  collaborator OTHER

• Vastra Gotaland Region

  collaborator OTHER_GOV

• Region Västerbotten

  collaborator OTHER_GOV

• Landstinget i Värmland

  collaborator OTHER

• ResMed

  collaborator INDUSTRY

• Swedish Heart Lung Foundation

  collaborator OTHER

• The Swedish Research Council

  collaborator OTHER_GOV

• Skane University Hospital

  lead OTHER

Principal Investigators

• Magnus Ekström, MD, PhD · Skane University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-06-10

Primary Completion

2027-12-31

Completion

2028-12-31

Countries

• Sweden

Study Locations