Impact of GLP-1 RAs Compared to Basal Insulin Start in Patients Living With Type 2 Diabetes and Chronic Kidney Disease
NCT06236672 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 348
Last updated 2024-02-01
Summary
The overall objective of this study is to compare the effectiveness of adding a glucagon-like peptide-1 receptor agonist compared with adding basal insulin for patients with type 2 diabetes and chronic kidney disease, already treated with an sodium-glucose cotransporter-2 inhibitor and not currently reaching target glycemic control. All sociodemographic information and clinical variables will be retrieved from the LMC Diabetes Registry.
Conditions
- Type 2 Diabetes
- Chronic Kidney Diseases
Interventions
- DRUG
-
GLP-1 receptor agonist
GLP-1 RA initiated between January 2019 and December 2022
- DRUG
-
basal insulin initiated between January 2019 and December 2022
Sponsors & Collaborators
-
Novo Nordisk Canada Inc.
collaborator UNKNOWN -
LMC Diabetes & Endocrinology Ltd.
lead OTHER
Principal Investigators
-
Alexander Abitbol, MD · LMC Diabetes & Endocrinology Ltd.
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-02-15
- Primary Completion
- 2023-11-29
- Completion
- 2023-11-29
Countries
- Canada
Study Locations
More Related Trials
-
Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD
NCT07309094 ·Status: RECRUITING
-
A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease
NCT06717698 ·Status: RECRUITING ·Phase: PHASE2
-
The Effect of Glucagon-like-peptide 1 (GLP-1) Receptor Agonism on Diabetic Kidney Disease
NCT01847313 ·Status: COMPLETED ·Phase: PHASE3
-
The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplant Recipients
NCT05938712 ·Status: RECRUITING ·Phase: PHASE2
-
Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes
NCT05822609 ·Status: RECRUITING ·Phase: PHASE2
-
A Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (the REMODEL Trial)
NCT04865770 ·Status: COMPLETED ·Phase: PHASE3
-
Glargine Versus NPH in Patients With Chronic Kidney Disease
NCT02451917 ·Status: COMPLETED ·Phase: PHASE4
-
A Research Study Looking Into Blood Levels of the Medicine NNC0519-0130 in the Body in Participants With Normal or Reduced Kidney Function
NCT06370819 ·Status: COMPLETED ·Phase: PHASE1
-
A Research Study of How a New Medicine NNC0148-0287 C (Insulin 287) Works in the Body of People With Kidney Problems
NCT03723785 ·Status: COMPLETED ·Phase: PHASE1
-
Antiproteinuric Effects of Liraglutide Treatment
NCT02545738 ·Status: COMPLETED ·Phase: PHASE4
-
A Research Study Looking Into Blood Levels of the Medicine NNC0480-0389 in Participants With Reduced Kidney Function Compared to Participants With Normal Kidney Function
NCT05015894 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetics of 10 mg Teduglutide in Subjects With Renal Impairment Compared to Healthy Subjects With Normal Renal Function
NCT01028768 ·Status: COMPLETED ·Phase: PHASE1
-
A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease
NCT03819153 ·Status: COMPLETED ·Phase: PHASE3
-
A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in Participants With Reduced Kidney Function and Normal Kidney Function
NCT06559527 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Various Degrees of Impaired Renal Function
NCT02014259 ·Status: COMPLETED ·Phase: PHASE1
-
Closed-Loop Impact on Chronic Kidney Disease in Type 2 Diabetes
NCT06925217 ·Status: RECRUITING ·Phase: NA
-
Effects of Linagliptin on Renal Endothelium Function in Patients With Type 2 Diabetes.
NCT01835678 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Look at the Effect MEDI0382 Has on Blood Sugar in People With Type 2 Diabetes and Kidney Problems and Also to Check That MEDI0382 is Well Tolerated
NCT03550378 ·Status: COMPLETED ·Phase: PHASE2
-
Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia
NCT06147232 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Study of the Effect of Renal Impairment on the Activity of GK Activator (2) in Patients With Type 2 Diabetes.
NCT00368368 ·Status: COMPLETED ·Phase: PHASE1
-
Glucagon-Like Peptide-1 Receptor Agonist in ADPKD
NCT06582875 ·Status: RECRUITING ·Phase: PHASE2
-
Reducing Risk of Diabetic Ketoacidosis in Type 1 Diabetes and Kidney Disease Using Continuous Ketone Monitoring
NCT07325201 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes and Moderate Renal Impairment
NCT02827708 ·Status: COMPLETED ·Phase: PHASE3
-
Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease
NCT06217302 ·Status: RECRUITING ·Phase: PHASE3
-
STUDY OF PF-06882961 IN PARTICIPANTS WITH TYPE 2 DIABETES MELLITUS WITH VARYING DEGREES OF RENAL IMPAIRMENT AND PARTICIPANTS WITHOUT RENAL IMPAIRMENT
NCT04616027 ·Status: COMPLETED ·Phase: PHASE1