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Low Dose Ketamine for Blunt Thoracic Trauma

NCT06236113 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2024-05-21

Study results available
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Summary

The goal of this Randomized controlled double-blinded trial is to compare the addition of a ketamine infusion to placebo, when added to standard care in adult blunt trauma patients with multiple rib fractures. The main question it aims to answer are: • addition of low dose ketamine infusion (LDKI) decreases narcotic use • does LDKI impact pulmonary complications, readmission, or hospital length of stay Participants will receive usual standard of care with up to 48 hours of LDKI or placebo. If there is a comparison group: Researchers will compare infusion of a saline infusion to LDKI to see if LDKI decreases need for narcotic analgesics use.

Conditions

  • Blunt Injury of Thorax
  • Multiple Rib Fractures, Involving Three Ribs

Interventions

DRUG

Ketamine 1 Mg/mL-NaCl 0.9% Intravenous Solution

administered at rate of 0.1 mg/kg/hr

Sponsors & Collaborators

  • North Memorial Health Care

    lead OTHER

Principal Investigators

  • Michaela A West, MD, PhD · North Memorial Health

  • Joseph Farhat, MD · North Memorial Health

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-10-01
Primary Completion
2023-03-19
Completion
2023-06-26
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06236113 on ClinicalTrials.gov