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Delta-8-THC vs. Delta-9-THC on Simulated Driving Performance

NCT06218550 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-09-25

No results posted yet for this study

Summary

Delta-8-THC is an isomer of delta-9-THC that has become widely available due to the legalization of hemp and its derivatives. Very little controlled research has been conducted with delta-8-THC and some research suggests it produces similar effects to delta-9-THC, albeit at lower potency. The present study will evaluate the dose effects of delta-8-THC, compared with delta-9-THC, on simulated driving performance, field sobriety tests, cognitive performance, and biomarkers of exposure to cannabinoids. The results will inform policy and education related to impairment due to acute delta-8-THC exposure via vaporization and oral ingestion.

Conditions

  • Cannabis

Interventions

DRUG

Delta-9-THC

Acute self-administration of inhaled or oral ∆9-THC by healthy adult research volunteers

DRUG

Delta-8-THC

Acute self-administration of inhaled or oral ∆8-THC by healthy adult research volunteers

DRUG

Placebo

Consumption of a brownie or inhalation of ambient air through a cannabis vaporizer by health adult research volunteers

Sponsors & Collaborators

  • Substance Abuse and Mental Health Services Administration (SAMHSA)

    collaborator FED

  • Johns Hopkins University

    lead OTHER

Principal Investigators

  • Ryan Vandrey, PhD · Johns Hopkins University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-07-01
Primary Completion
2025-09-08
Completion
2025-09-08
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06218550 on ClinicalTrials.gov