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Effect of Pulsatile Hormone Administration on Insulin Action

NCT06216665 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2025-01-16

No results posted yet for this study

Summary

In humans, insulin is secreted in pulses from the pancreatic beta-cells, and these oscillations help to maintain fasting plasma glucose levels within a narrow normal range. Given the fluctuations in insulin concentrations, oscillations enhance precision of control. The hyperinsulinemic euglycemic clamp test (clamp) involves a continuous infusion of insulin and is the gold standard for measuring insulin sensitivity. In this study, insulin sensitivity measured using the standard clamp will be compared with a clamp in which the same total amount of insulin as the standard clamp is infused every five minutes instead of continuously.

Conditions

  • Insulin Sensitivity

Interventions

OTHER

Continuous Insulin administration during hyperinsulinemic euglycemic clamp test

Participants will receive insulin delivered continuously during the hyperinsulinemic euglycemic clamp test

OTHER

Pulsatile Insulin administration during hyperinsulinemic euglycemic clamp test

Participants will receive insulin delivered every five minutes during the hyperinsulinemic euglycemic clamp test

Sponsors & Collaborators

  • Pennington Biomedical Research Center

    lead OTHER

Principal Investigators

  • Candida Rebello, PhD · Pennington Biomedical Research Center

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
50 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-03-04
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06216665 on ClinicalTrials.gov