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Dynamic Full-Field Optical Coherence Tomography for Structural and Microbiological Characterization of Central Venous Catheter-deposited Biofilm in Critically Ill Patients

NCT06216080 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2025-02-18

No results posted yet for this study

Summary

29.3% of bacteremias in intensive care units (ICU) are linked to vascular devices, with a significant proportion related to central venous catheters, and an influence on both morbility and mortality.

It is now accepted that microbiological biofilm plays a key role on both bacterial and fungal development on inner surface of vascular devices but there is yet a lack of clinical relevant data documenting a causal relation between biofilm formation and bacteremias.

We assume that a more precise characterization of central venous catheter-deposited biofilm could help us better understand invasive medical device-related healthcare infections in critically ill patients.

Conditions

  • Healthcare Associated Infection
  • Critically Ill
  • Central Venous Catheter Associated Bloodstream Infection

Interventions

OTHER

D-FF-OCT analysis of CVC

Dynamic full-field optical coherence tomography analysis of central venous catheter sections to better apprehend strucural characterization of central venous catheter-deposited biofilm

Sponsors & Collaborators

  • Centre Hospitalier Universitaire Dijon

    collaborator OTHER

  • Centre Hospitalier William Morey - Chalon sur Saône

    lead OTHER

Principal Investigators

  • Thomas Maldiney · William Morey General Hospital (Chalon-sur-Saône)

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-05-01
Primary Completion
2024-12-30
Completion
2025-02-10

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06216080 on ClinicalTrials.gov