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The Target Urine VOCs Biosensor for Genitourinary Malignancy Detection

NCT06211010 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 64

Last updated 2024-01-18

No results posted yet for this study

Summary

Volatile organic compounds (VOCs) have grown due to their crucial role in transitioning from invasive to noninvasive cancer diagnostic methods. This study aimed to assess the feasibility of the metal oxide biosensor platform using urine VOCs for detecting genitourinary cancers.

Five different commercially available semiconductor sensors were chosen to detect specific VOCs (methane, iso-butane, hydrogen, ethanol, hydrogen sulfide, ammonia, toluene, butane, propane, trimethylamine, and methyl-mercaptan). Changes in electrical resistance due to temperature variations from the voltage heater were examined to characterize VOC metabolism. Logistic regression and ROC analysis were employed to evaluate potential urine VOCs for genitourinary cancer determination.

Conditions

  • The Phenomenon of the Decrease in the Electrical Resistance Within the Conducting Chambers, Making the Increase in a Conducting Property

Interventions

DIAGNOSTIC_TEST

the semiconductor metal oxide sensors.

The method of analyzing the VOCs was through analyzing the evaporated VOCs from the urine in the container when they evaporated into the sealed chamber. The VOCs in the chamber were then analyzed at the same time by the five different gas semiconductor sensors which were located on the top of the chamber.

Sponsors & Collaborators

  • Suranaree University of Technology

    lead OTHER

Principal Investigators

  • Chatchai Kreepala, M.D. · School of Internal Medicine, Institute of Medicine, Suranaree University of Technology, Thailand

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-12-01
Primary Completion
2023-09-01
Completion
2023-11-01

Countries

  • Thailand

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06211010 on ClinicalTrials.gov