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Prognostic Significance of CMD Assessed by IMR in HCM Patients

NCT06190704 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 191

Last updated 2024-01-08

No results posted yet for this study

Summary

The index of microcirculatory resistance (IMR) serves as an indicator of coronary microvascular dysfunction (CMD) with significant prognostic value in various clinical conditions. However, its impact on CMD in the hypertrophic cardiomyopathy (HCM), whether assessed invasively or non-invasively, is yet to be investigated. We assessed the prognostic importance of CMD using less invasive coronary angiography-derived IMR (caIMR) in HCM patients with nonobstructive epicardial coronary arteries.Patients with HCM who underwent invasive coronary angiography for suspected myocardial ischemia were included. Microvascular function was assessed using caIMR, and 460 coronary arteries were analyzed. CMD was identified with caIMR\>25U, in line with prior research, and the primary study endpoint was major adverse cardiac events (MACE).

Conditions

  • Coronary Cicrovascular Dysfunction
  • Hypertrophic Cardiomyopathy Patients

Interventions

DEVICE

caIMR

Coronary angiography-derived IMR (caIMR) is a novel and accurate alternative that can enable the assessment of coronary microvascular function easier, and more efficiently and does not require pressure wire or adenosine.

Sponsors & Collaborators

  • Ya-Wei Xu

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-09-13
Primary Completion
2023-05-31
Completion
2023-05-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06190704 on ClinicalTrials.gov