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Use of Cinnamomum Verum for Induction of Labor. Double Blind Randomized Clinical Trial

NCT06164613 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2025-12-04

No results posted yet for this study

Summary

The purpose of the research protocol is to evaluate the effectiveness of Cinnamomum verum extract for the initiation of labor. Cinnamaldehyde ((E)-3-Phenylprop-2-enal) is an α, β unsaturated aromatic aldehyde, derived from cinnamon (Cinnamomum Verum oil) used as a flavoring; It is a clear yellowish liquid substance, with a strong odor and flavor. It is the main component of cinnamon (63%), giving it its physicochemical properties. Cinnamon has been an element of empirical use for the beginning of labor, however, its effectiveness has not been demonstrated.

Cinnamon has been reported for its ethnopharmacological properties in pregnancy, being used to facilitate childbirth, as a lactagogue and for postpartum recovery. In Honduras, its use has been reported to relieve nausea and vomiting during pregnancy, to reduce abdominal pain. , reduction of lower limb edema, to relieve anxiety during labor, as well as a lactagogue without convergent opinions.

Conditions

  • Labor Onset and Length Abnormalities
  • First Birth

Interventions

DRUG

Cinnamomum Verum oil extract

one capsule of 1000 mg orally of Cinnamomum Verum oil extract per day for 21-28 days

DRUG

Placebo

400 mg PO Canola oil soft gel capsule

Sponsors & Collaborators

  • Universidad Nacional Autonoma de Honduras

    lead OTHER

Principal Investigators

  • Ricardo A. Gutierrez Ramirez, MD, MSc · Universidad Nacional Autonoma de Honduras

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
14 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-12-04
Primary Completion
2026-12-30
Completion
2026-12-30
FDA Drug
Yes

Countries

  • Honduras

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06164613 on ClinicalTrials.gov