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D-SOLVE Cohorts (Cohort a and B)

NCT06160635 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 750

Last updated 2025-03-12

No results posted yet for this study

Summary

Hepatitis D is by far the most severe form of chronic viral hepatitis, frequently leading to liver failure, hepatocellular carcinoma and death. Hepatitis D is caused by coinfection Hepatitis D is caused by co-infection with hepatitis B virus (HBV) and hepatitis D virus (HDV).

This multicenter cohort should enable a comprehensive and unbiased biomarker screening of well-defined HDV-infected patients, followed by mechanistic studies to determine the functional role of distinct molecules. Patient surveillance strategies and antiviral treatment approaches could be personalized which should reduce clinical and social disease burden, improve quality of life and save direct and indirect costs caused by HDV infection.

Conditions

Sponsors & Collaborators

  • Karolinska University Hospital

    collaborator OTHER

  • Karolinska Institutet

    collaborator OTHER

  • Helmholtz Centre for Infection Research

    collaborator OTHER

  • Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

    collaborator OTHER

  • National Institute of Infectious Diseases Matei Bals

    collaborator UNKNOWN

  • Hannover Medical School

    lead OTHER

Principal Investigators

  • Markus Cornberg · Hannover Medical School

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-22
Primary Completion
2026-09-30
Completion
2026-09-30

Countries

  • Germany
  • Italy
  • Romania
  • Sweden

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06160635 on ClinicalTrials.gov