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Fisetin to Improve Vascular Function in Older Adults

NCT06133634 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2025-11-12

No results posted yet for this study

Summary

This is a pilot clinical trial to test the efficacy of intermittent treatment with the flavonoid compound fisetin for improving vascular endothelial function and reducing aortic stiffness in older adults. This trial will also determine the potential mechanisms by which fisetin may improve vascular function, including by decreasing mitochondrial oxidative stress, cellular senescence and senescence-associated secretory phenotype (SASP) factors in circulation. Lastly, safety, tolerability and adherence of fisetin treatment will be assessed.

Conditions

  • Aging
  • Endothelial Dysfunction
  • Arterial Stiffness

Interventions

DIETARY_SUPPLEMENT

Fisetin

Fisetin dietary supplement

OTHER

Placebo

Placebo capsules identical in appearance to fisetin capsules

Sponsors & Collaborators

Principal Investigators

  • Matthew J Rossman, PhD · University of Colorado, Boulder

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-09-25
Primary Completion
2026-03-31
Completion
2027-03-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06133634 on ClinicalTrials.gov