Spatial Location of Breast Cancer Local Recurrence After Mastectomy

Summary

Rationale:To improve the definition of the target volume for radiotherapy of the chestwall after different types of mastectomy, the exact localization of regions at risk for a local recurrence should be known. However, there are currently insufficient data in literature showing where local recurrences occur after different types of mastectomy.

Objective: The primary objective of the proposed study is to determine whether the spatial, location of a breast cancer recurrence after mastectomy, differs for different types of mastectomy.

Study design: Retrospective study evaluating spatial location and site of recurrences after mastectomy.

Study population: The investigators aim to include all breast cancer patients treated with mastectomy in the Netherlands between 2003- 2008, and known to have experienced a local recurrence as the first site of failure.

Primary endpoint: Spatial location of local recurrence (e.g., primary tumour bed, scar, skin, subcutaneous, nipple, areola, pectoral muscles).

Conditions

• Breast Cancer

Interventions

PROCEDURE

Mastectomy

Mastectomy as a surgical procedure for breast cancer (regardless of perioperative treatment).

Sponsors & Collaborators

• Albert Schweitzer Hospital

  collaborator OTHER

• Canisius-Wilhelmina Hospital

  collaborator OTHER

• Diakonessenhuis, Utrecht

  collaborator OTHER

• Erasmus Medical Center

  collaborator OTHER

• Franciscus Gasthuis

  collaborator OTHER

• Haaglanden Medical Centre

  collaborator OTHER

• Jeroen Bosch Ziekenhuis

  collaborator OTHER

• Maastricht University Medical Center

  collaborator OTHER

• Maxima Medical Center

  collaborator OTHER

• St. Antonius Hospital

  collaborator OTHER

• Laurentius ziekenhuis

  collaborator UNKNOWN

• VieCuri Medical Centre

  collaborator OTHER

• NKI-AvL

  collaborator UNKNOWN

• Ziekenhuis Netwerk Antwerpen (ZNA)

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• Sheba Medical Center

  collaborator OTHER_GOV

• University of Florence

  collaborator OTHER

• Maastricht Radiation Oncology

  lead OTHER

Principal Investigators

• Liesbeth Boersma, Prof. · Maastro

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-09-01

Primary Completion

2023-12-01

Completion

2024-01-01

Countries

• Netherlands

Study Locations